Beth Israel PET/CT viewer have been used in many scientific purposes :


  • Brown fat quantification :


Identification and importance of brown adipose tissue in adult humans

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR.

N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780.


Mapping of human brown adipose tissue in lean and obese young men

Brooks P. Leitner, Shan Huang, Robert J. Brychta, Courtney J. Duckworth, Alison S. Baskin, Suzanne McGehee, Ilan Tal, William Dieckmann, Garima Gupta, Gerald M. Kolodny, Karel Pacak, Peter Herscovitch, Aaron M. Cypess, and Kong Y. Chen

PNAS 2017 published ahead of print July 24, 2017doi:10.1073/pnas.1705287114


Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Katherine Kim, Shan Huang, Laura A. Fletcher, Alana E. O'Mara, Ilan Tal, Robert J. Brychta, Aaron M. Cypess, Kong Y. Chen, Brooks P. Leitner

JOVE 2018


  • Metabolic Tumor Volume :


Influence of Software Tool and Methodological Aspects of Total Metabolic Tumor Volume Calculation on Baseline [18F]FDG PET to Predict Survival in Hodgkin Lymphoma.

Kanoun S, Tal I, Berriolo-Riedinger A, Rossi C, Riedinger JM, Vrigneaud JM, Legrand L, Humbert O, Casasnovas O, Brunotte F, Cochet A.

PLoS One. 2015 Oct 16;10(10):e0140830. doi: 10.1371/journal.pone.0140830. eCollection 2015.


Baseline Metabolic Tumor Volume Predicts Outcome in High-Tumor-Burden Follicular Lymphoma: A Pooled Analysis of Three Multicenter Studies.

Meignan M, Cottereau AS, Versari A, Chartier L, Dupuis J, Boussetta S, Grassi I, Casasnovas RO, Haioun C, Tilly H, Tarantino V, Dubreuil J, Federico M, Salles G, Luminari S, Trotman J.

J Clin Oncol. 2016 Aug 22. pii: JCO669440


Predictive value of PET response combined with baseline metabolic tumor volume in peripheral T-cell lymphoma patients.

Cottereau AS, El-Galaly TC, Becker S, Broussais F, Peterson LJ, Bonnet C, Prior JO, Tilly H, Hutchings M, Casasnovas O, Meignan MA.

J Nucl Med. 2017 Sep 1. pii: jnumed.117.193946. doi: 10.2967/jnumed.117.193946


Prognostic value of baseline metabolic tumor volume in early stage Hodgkin's lymphoma in the standard arm of H10 trial.

Cottereau AS, Versari A, Loft A, Casasnovas O, Bellei M, Ricci R, Bardet S, Castagnoli A, Brice P, Raemaekers J, Deau B, Fortpied C, Raveloarivahy T, Van Zele E, Chartier L, Vander Borght T, Federico M, Hutchings M, Ricardi U, Andre M, Meignan M.

Blood. 2018 Feb 1. pii: blood-2017-07-795476. doi: 10.1182/blood-2017-07-795476.


Metabolic Tumour Volume for Response Prediction in Advanced-Stage Hodgkin Lymphoma.

Mettler J, Müller H, Voltin CA, Baues C, Klaeser B, Moccia A, Borchmann 2, Engert A, Kuhnert G, Drzezga AE, Dietlein M, Kobe C1

J Nucl Med. 2018 Jun 7. pii: jnumed.118.210047. doi: 10.2967/jnumed.118.210047.


  • Prostate Cancer :


18F-Choline Positron Emission Tomography/Computed Tomography and Multiparametric Magnetic Resonance Imaging for the Detection of Early Local Recurrence of Prostate Cancer Initially Treated by Radiation Therapy: Comparison With Systematic 3-Dimensional Transperineal Mapping Biopsy.

Kanoun S, Walker P, Vrigneaud JM, Depardon E, Barbier V, Humbert O, Moulin M, Créhange G, Cormier L, Loffroy R, Brunotte F, Cochet A.

Int J Radiat Oncol Biol Phys. 2017 Apr 1;97(5):986-994. doi: 10.1016/j.ijrobp.2016.12.025.


Fluorine-18-fluorocholine PET/CT parameters predictive for hematological toxicity to radium-223 therapy in castrate-resistant prostate cancer patients with bone metastases: a pilot study

Vija Racaru, Lavinia; Sinigaglia, Mathieu; Kanoun, Salim; Ben Bouallègue, Fayçal; Tal, Ilan; Brillouet, Sévérine; Bauriaud-Mallet, Mathilde; Zerdoud, Slimane; Dierickx, Lawrence; Vallot, Delphine; Caselles, Olivier; Gabiache, Erwan; Pascal, Pierre; Courbon, Frederic

Nuclear Medicine Communications: May 08, 2018 - doi: 10.1097/MNM.0000000000000850

  • Response assessment :

FDG PET/CT for prognostic stratification of patients with metastatic breast cancer treated with first line systemic therapy: comparison of EORTC criteria and PERCIST. 

E. Depardon, S. Kanoun, O. Humbert, JM Rieidinger, I.Tal, JM Vrigneaud,  M. Lasserre, M. Toubeau, A. Berriolo-Riedinger, I. Dygai-Cochet, P. Fumoleau, F. Brunotte, A. Cochet, A Bertaut. 

PLoS One. 2018 Jul 16;13(7):e0199529. doi: 10.1371/journal.pone.0199529. eCollection 2018.